About us

XBiotech USA Inc. is fully integrated biopharmaceutical company developing a diversified portfolio of biologics across multiple therapeutic areas. We are advancing several assets from early clinical development through commercialization, with a mission to transform patient outcomes through groundbreaking science. From pre-clinical models to clinical trial execution, from discovery to manufacturing, all activities are under one roof.

XBiotech is focused on developing antibody therapeutics targeting the major medical needs of inflammatory diseases, cancer and infectious diseases. XBiotech’s drug Research & Development center is headquartered in Austin, Texas. Our Austin facility incorporates all critical operations including discovery, research and development, drug testing, product formulation as well as clinical-regulatory affairs. Our excellent facilities allow us to effectively implement and fully develop any program we adopt. We are working to change the future of medicine.

Position Overview

We are seeking a Medical Director with proven early-stage pharmaceutical/biotechexperience to provide medical leadership across our multi-therapeutic area biologicsportfolio. This role requires exceptional generalist capabilities combined withcollaborative leadership skills; someone who can effectively leverage externaltherapeutic area experts, key opinion leaders, and clinical consultants to ensure bothscientific rigor and operational agility. You will serve as a trusted medical voice internallyand externally, seamlessly bridging clinical development and medical affairs as weadvance our pipeline.

Key Responsibilities

Clinical Development & Multi-Program Medical Oversight

Provide medical oversight and strategic input for clinical trials across multiple therapeutic areas including oncology, rheumatology and infectious diseases
Collaborate with cross-functional teams to design clinical development plans and study protocols for diverse indications
Serve as medical monitor for clinical trials, ensuring patient safety and data integrity across programs
Coordinate with therapeutic area consultants and advisors to ensure clinical and scientific expertise for each program
Review and interpret clinical data across different therapeutic areas to guide development decisions and regulatory strategies
Contribute to regulatory submissions including INDs, and responses to health authority queries

Expert Network & KOL Management

Build and manage a network of therapeutic area experts, clinical consultants, and scientific advisors
Establish relationships with key opinion leaders (KOLs) across multiple therapeutic areas
Coordinate scientific advisory boards and leverage external expertise for study design and data interpretation
Identify and engage consultants for specific therapeutic area needs as programs advance
Synthesize input from multiple experts to make informed medical and strategic decisions

Medical Affairs Leadership

Build and lead medical affairs capabilities as the company scales
Create scientific communication materials including publications, presentations, and medical education content
Establish relationships with key opinion leaders (KOLs) and scientific advisory boards
Oversee investigator-initiated studies

Cross-Functional Collaboration & Leadership

Partner with regulatory affairs to ensure scientific rigor in submissions across therapeutic areas
Work closely with clinical operations to ensure trial execution aligns with medical objectives
Prioritize resources and balance competing demands across multiple programs

External Engagement & Representation

Represent the company at scientific conferences and medical meetings across relevant therapeutic areas
Present clinical data to investigators, healthcare professionals, and scientific audiences
Engage with patient advocacy groups to understand unmet medical needs
Participate in scientific discussions with regulators

Qualifications

Required

MD, or equivalent medical degree with active medical license
Minimum 5-7 years of clinical medicine and/or pharmaceutical industry experience in an early stage pharma/biotech company
Strong understanding of biologics development, including regulatory pathways and CMC considerations
Demonstrated experience in clinical trial design, execution, and medical monitoring across multiple programs
Proven ability to work effectively with external consultants and leverage therapeutic area expertise
Experience coordinating scientific advisory boards and managing expert networks
Deep knowledge of drug development lifecycle from IND through commercialization
Experience with FDA and international regulatory agencies
Excellent scientific writing and communication skills with ability to synthesize complex information
Strong organizational skills and ability to prioritize across multiple concurrent projects
Proven ability to work effectively in a fast-paced, resource-constrained entrepreneurial environment
Comfort with ambiguity and ability to make sound decisions with incomplete information

Preferred

Board certification in internal medicine, oncology, immunology, or another relevant therapeutic specialty
Prior experience in startup or emerging biotech companies, particularly with limited resources
Experience managing clinical programs across 2-3 therapeutic areas simultaneously
Track record of publications in peer-reviewed journals across different therapeutic areas
Previous medical affairs or medical leadership experience
Experience working with CROs and external clinical development partners

Competencies

Strategic thinking with ability to balance scientific rigor across diverse programs
Strong leadership presence and ability to influence without authority, especially when working with external experts
Excellent judgment in knowing when to seek deep therapeutic area expertise versus leveraging generalist knowledge
Highly collaborative mindset with excellent interpersonal and relationshipbuilding skills
High ethical standards and unwavering commitment to patient safety

Exceptional analytical and problem-solving skills
Intellectual curiosity and willingness to learn across therapeutic areas
Adaptability and resilience in a dynamic startup environment with evolving priorities
Efficient time management and ability to context-switch between different programs
Comfort operating independently while building networks of support and expertise

What Makes This Role Unique

This position offers a unique opportunity to shape medical strategy across a diverse portfolio while building a best-in-class network of therapeutic area experts.

You'll have the autonomy to structure collaborations and expert engagement in ways that maximize scientific quality while optimizing resources.

The ideal candidate thrives on variety, enjoys the intellectual challenge of working across disciplines, and excels at orchestrating diverse expertise to drive programs forward.

Travel

Approximately 20-30% travel expected eventually for conferences, investigator meetings, advisory boards, and site visits across therapeutic areas

Compensation

Competitive salary and equity package commensurate with experience, plus comprehensive benefits including health insurance, and retirement plans. XBiotech USA Inc. is an equal opportunity employer committed to diversity and inclusion in the workplace.

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Medical Director

Key Responsibilities

Clinical Development & Multi-Program Medical Oversight

Expert Network & KOL Management

Medical Affairs Leadership

Cross-Functional Collaboration & Leadership

External Engagement & Representation

Qualifications

Competencies

Role summary

Medicine should make you feel better, not worse

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