Inflammatory skin conditions encompass a wide range of diagnoses from common conditions such as acne, eczema, and psoriasis, to more rare conditions such as pyoderma gangrenosum. One common factor unifying the pathophysiology of these conditions is Interleukin-1 alpha. IL-1α is an extremely potent pro-inflammatory cytokine, which has long been associated with the skin. Keratinocytes are large reservoirs for preformed, intracellular, and biologically active IL-1α, which is believed to be a key factor in the initiation of skin inflammation. Blockade of this inflammatory signal with MABp1 promises a safe and effective treatment for numerous dermatologic conditions.